You can fly directly from Newark via Continental Airlines, from Philadelphia via US Airways, from Atlanta via Delta Connection, from New York via jetBlue Airways, and from Orlando via jetBlue Airways and Pan Am into Rafael Hernandez International Airport. Hotels have shuttles to and from the airport.
Isabela is serve by Interstate PR-2. I-PR-2 to the East connects it with Quebradillas, Camuy, Hatillo, and eventually to San Juan via Arecibo. To the West with Aguadilla and from there, it connects it with Aguada and Añasco to the South. Other roads include State-Road 459 to San Antonio Village, State-Road 4466 to Bajuras and Jobos two great beach spots.