Amtrak trains come from Los Angeles, New Orleans, and Chicago via San Antonio. The station is located at 100 North Main Street and is an intermodal transportation center, with buses in addition to trains.
The Del Rio Regional Transportation Center at 100 North Main Street houses several intercity bus lines, as well as local transit and Amtrak passenger rail services.
US 277 from Sonora on I-10 (about 80 miles north) or US 90 from San Antonio (about 200 miles east).
Del Rio International Airport is used mainly by general aviation aircraft. The closest major airport is in San Antonio.
The best way is by personal car. There is at least one taxi company.
Laughlin Air Force Base is located just outside Del Rio.
The major attraction in the Del Rio area is Amistad National Recreation Area , where camping, boating, and fishing are available (the Bassmasters Elite tournament was held here for four years in a row until 2008). At Lake Amistad, visitors can also find 4,000-year-old Indian pictographs, which are accessible only by boat at Panther Cave and at Parida Cave.
Val Verde Winery  in the downtown area offers a wine-tasting of about a dozen of their wines for about $5 per person or a free tasting of only three. Their wines are excellent and range from sweet (notably the San Felipe del Rio red, their Texas Rose, and their Muscat Cannelli) to exceptionally dry (Cabernet Sauvignon), but their port has won awards. Most of their wines are blends with grapes from other vineyards, but one is made of only grapes grown at the winery.
Karaoke at Lorina's Cantina (see below) on Saturday nights.
Del Rio has one, relatively small, indoor mall with typical mall stores: Beall's, Penney's, etc. and the town cinema with several screens.
The Adrian Falcon Gallery  offers contemporary art by Del Rio native Adrian Falcon.
The downtown area has numerous shops, including several antique shops and a few selling rustic furniture.
La Hacienda is a Mexican restaurant downtown that offers an excellent buffet of Mexican food for a very reasonable price. One item not on the menu is "cabrito" (goat), which you have to ask for and it is excellent, succulent meat, beautifully roasted. Each day the restaurant roasts one goat in the morning and sells it until it runs out. Get there early! Their coffee is great and compares well to Starbuck's.
Lorina's Cantina, outside of town on US 90 toward the Lake, has steak night on Wednesdays from 6:00 to 8:00. Call ahead to reserve a steak. The steaks are about 3/4 to 1 lb in size, thick cut, wonderful, beautifully seasoned, succulent, and come with a baked potato and salad (only lettuce and dressings) bar for only $13 per person. This is a real meal for meat-and-potato-kind-of-guys.
T&B (Todd and Bullet's) Bar and Grill next to the Day's Inn on US 90 has good food and a good bar. Anthony Bourdain of the Travel Channel once came here for their Corona Chicken, which is succulent pieces of chicken about the size of the neck of a Corona bottle filled with cheese and wrapped in bacon.
Chinto's on Sixth street has excellent Mexican food and generous portions in a comfortable atmosphere for very reasonable prices. Hours about 6:00 a.m. to 2:30 p.m. (per many traditional Mexican restaurants).
Standard fast food (Wendy's, Whataburger, etc.) and chains (Chili's, Luby's, etc.) are available.
There is one Thai restaurant, Jitra's, in town with mediocre Thai food.
Lorina's Cantina and TB's are excellent places for relaxing evenings with a beer and friends. TB's also offers excellent food seven nights a week, while Lorina's offers steaks on Wednesday nights from 6 to 8.
For a glass of wine in a quiet, comfortable atmosphere, Casa de Vino on US 90 near Lake Amistad (not far from Lorina's) is the place to go. It offers about 300 different wines and a small appetizer menu in a comfortable, very clean setting. Casa de Vino also offers a small patio for watching the sun set on warm evenings.
The Herald Martini Bar is probably the classiest place in town and a good place to go for a nice dinner and drinks.