Darende is located on highway D300 which connects Malatya with major cities of the country such as Ankara and Istanbul. The distance to Malatya is 110 km, while Sivas is 180 km away and Kayseri 250 km. There are buses from these centres to Darende.
The nearest airport is Erhaç (near Malatya) which receives daily flights from Ankara and Istanbul. The airport is 80 km away from Darende.
Make time to walk around the town. It's quite small but very typically Turkish and the people are very friendly.