The East Side is a district in Cleveland consisting of the areas outside of Downtown that are east of the Cuyahoga River. The district incorporates the neighborhoods of University Circle, Little Italy, and Shaker Square.
Three two-digit interstate highways serve Cleveland directly.
Interstate 71 begins downtown and is the major route from downtown Cleveland to the airport. I-71 runs through the southwestern suburbs and eventually connects Cleveland with Columbus.
Interstate 77 begins in downtown Cleveland and runs almost due south through the southern suburbs. I-77 sees the least traffic of the three interstates, even though it is the primary connector of Cleveland with Akron.
Interstate 90 connects the two sides (the terms "East Side" and "West Side" have deep root in defining this region) of Cleveland, and is the northern terminus for both I-71 and I-77. Running due east/west through the West Side suburbs, I-90 turns northeast at the junction with I-71 and I-490, and is known as the Innerbelt through downtown. At the junction with the Shoreway, I-90 makes a 90-degree turn known as "Dead Man's Curve", then continues northeast, entering Lake County at the eastern split with Ohio 2.
Interstate 480 runs east-west along the southern border of the City of Cleveland and also connects the suburbs of the East Side and West Side. It intersects all three of the above highways, plus it intersects I-271, which serves the eastern suburbs, and I-480 has two connections to the Ohio Turnpike, I-80.
University Circle  is located about four miles east of downtown and can be reached via Euclid Avenue. The "circle" itself is a large open area that is often filled with frisbee-tossing college students, but its main attractions are the numerous museums, research institutes and schools which surround it. This rich cultural menagerie is surpassed by few places in North America (e.g., perhaps the Smithsonian Institute in Washington, D.C.).
Cleveland Museum of Art, 11150 East Boulevard, . Internationally renowned for its substantial holdings of Asian and Egyptian art, the museum houses a diverse permanent collection of more than 43,000 works of art from around the world. free. edit
Western Reserve Historical Society, 10825 East Blvd, ☎ ''+1 (216) 721-5722, . Includes two turn of the (20th) century mansions as well as displays about Cleveland history from the days of Moses Cleaveland to the present. The buildings also house the Crawford Auto-Aviation Museum and an extensive Cleveland historical research library.edit
Children's Museum of Cleveland, 10730 Euclid Avenue (University Circle), ☎ +1-(216)-791-7114 (fax: +1-(216)-791-8838), . Hours: Tuesday - Saturday: 10 - 17:00, Sunday: Noon - 17, Closed Mondays.. Admission: Everyone: $6.00, Children under 11 months: Free. edit
Museum of Natural History
Cleveland Museum of Natural History, 1 Wade Oval Drive (University Circle), ☎ +1-(216)-231-4600, . Hours: Monday - Saturday: 10 - 17, Wednesday 10 - 22:00, Sunday: Noon - 17. Closed: Memorial Day, Independence Day, Labor Day, Thanksgiving Day, Christmas Day and New Year’s Day. edit
Crawford Auto-Aviation Museum, ☎ +1-(216)-721-5722, . Hours: Monday - Saturday: 10 - 17, Sunday: Noon - 17. Home to an excellent collection of pre-war automobiles, as well as the very first DeLorean DMC-12 to roll off the assembly line. Admission: Adults: $8.50, Seniors: $7.50, Students: $5.00, Children (under 2 years): Free. edit
Dittrick Medical History Center and Museum, 11000 Euclid Avenue, Allen Memorial Medical Library, ☎ +1-(216)-368-6391 (firstname.lastname@example.org, fax: +1-(216)-368-0165), . Hours: Monday - Friday: 10:00 - 16:00. Closed Saturdays and Sundays; January 1, Martin Luther King, Jr. Birthday Observance, Memorial Day, July 4, Labor Day, Thanksgiving and the day after.. Admission: Free. edit
Temple Museum of Religious Art, 1855 Ansel Road, The Temple-Tifereth Israel (University Circle at Silver Park), ☎ +1-(216)-831-3233, . Museum tours are available by appointment Monday - Friday from 09 - 16:00. edit
Cleveland Botanical Garden, 11030 East Boulevard (University Circle), ☎ +1-(216)-721-1600 (email@example.com, fax: +1-(216)-721-2056), . Winter Hours: November 1 - April 1: Tuesday - Saturday: 10 - 17:00, Sunday: Noon - 17. Closed Mondays. (Hershey Children's Garden closes November 1st for the winter. All other gardens remain open throughout the winter.); Summer Hours: April 1 - November 1: Monday - Saturday: 10 - 17:00, Sunday: Noon - 17. Open until 9:00 p.m. every Wednesday evening from Memorial Day to Labor Day. This Cleveland treasure includes a huge glasshouse, home to a Madagascar Desert and a Costa Rican rain forest. Outside exhibits include a rose garden, an herb garden, and a children's garden, one of just a few such gardens in the United States. Admission: Adult: $7.50, Children (3-12): $3, Children (under 3): Free. Prices may change for special events.. edit
Lake View Cemetery, a beautiful setting where many famous people are buried, including President James A. Garfield, John D. Rockefeller - founder of Standard Oil, Jeptha Wade - founder of Western Union Telegraph, Eliot Ness - head of The Untouchables, John Hay - U.S. Secretary of State under President Lincoln, Newton Baker - U.S. Secretary of War during WWI, Marcus L. Hanna - U.S. Senator and Republican Party Boss.
Presti's Donuts, 12409 Mayfield Road (Little Italy), ☎ +1-(216)-791-3272. A Little Italy institution, Presti's donuts has existed for years and provides homemade baked goods including donuts that are often cited as some of the best in America. edit
Mama Santa's Restaurant and Pizzeria, 12305 Mayfield Road, ☎ +1-(216)-231-9567. Another Little Italy institution, Mama Santa's offers inexpensive but tasty Italian fare in a family-run environment. edit
Nighttown, 12387 Cedar Road, ☎ +1-(216)-795-0550 (firstname.lastname@example.org, fax: +1-(216)-795-0531), . Hours: Mon. – Thurs.: 11:30 - Midnight, Fri. & Sat.: 11:30 - 01:00, Sunday Brunch: 10:00 - 15:00, Sunday Dinner: 15:00 - Midnight. This full-service, white tablecloth restaurant is the only jazz club in Ohio on Down Beat's list of the 100 Best Jazz Clubs in the World. The food is great too. edit
Baricelli Inn, (Little Italy). Quaint bed and breakfast feel above fine Italian restaurant.edit
Glidden House, 1901 Ford Drive, ☎ 866-812-4537, . A renovated and expanded mansion in University Circle on the campus of Case Western University. This is one of the most luxurious lodging options in Cleveland.edit