Low key town. you cross through it to get to bocas from puerto viejo/ costa rica. a nice town, but i wouldnt feel safe there at night. during the day it is fine...The best and cheapest clothes ever. make sure to pack light so you can pick up some clothes from this town. it has a really interesting vibe, in a good way. some sweet local restaurants.
Flights into Changuinola's Manuel Nino International Airport from Panama City Albrook Marcos Gelabert Airport by AirPanama, from the capital everyday (60 mins $160/$230 after tax and fees, each way.) *** As of March 1, 2012, Aeroperlas has suspended operations, so Air Panama is the only option.
From Panama City Albrook Bus Terminal Tranceibosa bus line, two buses per night from 9pm/10pm. (12 hours)
From David Bus Station mid-size buses every hour (5 hours ride).
From Sixaola-Guabito Costa Rica border you could take a pickup taxi $1.50 or regular bus $0.75, taxi is recommended, extremely fast (15 minutes).