This is the area where "Crossroads of America" really comes into play. Numerous interstates and highways swarm into this area. I-65S from the northwest, I-74E from the west, I-70E from the southwest, I-65N from the south, I-74W from the southeast, I-70W from the east, and I-69S from the northeast. Indianapolis has a loop called I-465.
Anderson - Economy Inn, 2400 S. Scatterfield Rd. +1 765 642-3931
Indianapolis - 350 S. Illinois St. +1 317 267-3076
Megabus, +1 877 G02-MEGA, . A super cheap way to travel by bus that was brought from Europe to the Midwest. Clean, friendly travel option. The earlier you book your trip the cheaper it is. All pickup/drop off points are at popular landmarks. Pickup/drop off from three points in Indy:
Indianapolis City Market - 222 E. Market St.
Circle Center Mall - 40 W. Maryland St.
Indianapolis Motor Speedway - 4790 W. 16th St.
Burlington Trailways1 800 992-4618.  Offers bus service throughout the Midwest. Pickup/drop off in Indianapolis.