Calexico is located at the southern end of Highway 111, and in the middle of Highway 78 E-W. From San Diego, take I-8 to Highway 78; the trip lasts about two hours.
Calexico is served by Greyhound from Los Angeles (around 6 hours) or San Diego (around 4 hours).
- Most visitors to Calexico arrive on foot from the sister city Mexicali. From downtown Calexico it's a short walk to the border crossing and several tourist areas on the other side. U.S. citizens do not require a passport for short trips to the border area of Mexico.
- A few miles west of Calexico on Highway 98 is the Mount Signal Cafe. This small cantina is owned by a former female professional bullfighter.
- Rubin No. II, five to six blocks south of 98 and one block west of Imperial (CA 111) lies a small hole in the wall Mexican and Chinese restaurant on Emerson Street.
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