Cairo Custom House Museum, 14th and Washington Ave, +1 618 734-9632. An American Civil War and local history museum. M-F 10AM-12PM, 1PM-3PM.
Fort Defiance State Park. This once neglected state park has come back into better days thanks to local efforts. It looks out over the Ohio and Mississippi rivers as the two powerful water flows attempt to combine.
Safford Memorial Library, 1609 Washington Ave, +1 618 734-1840. Home to Civil War documents, antiques, and paintings. M-F 10AM-5PM, Sa 9AM-12PM.