Brest – the center of the region. Brest Fortress is one of the basic memorials of the World War II. The memorial park also includes the archaeological museum of Berestye, the ancient settlement on the spot of Brest. The city itself is less remarkable, although it preserves several churches from 19th century and an interesting railway museum.
Baranavičy – a yound city with a number of modern churches and an interesting railway museum.
Kamianiec – a town with a well preserved 13th century tower (sometimes called Belaya Vezha, or the White Tower, despite actually being red).
Pinsk – one of the most remarkable cities in Belarus with numerous churches, monasteries, and secular buildings from 17th – 19th century.
Pružany – a small town that preserves a nice country estate and several fine churches from 19th century.
Biaroza – a small town with the remains of the monastery from 17th century.
Kobryn – an ancient town that keeps secular buildings from 19th century and the museum of Suvorov.
Kosava – a small town with the remains of the medieval-like castle from 19th century. The home-town of the Polish national hero Tadeusz Kościuszko, the house museum of whom was opened there in September, 2004 .
Bielaviežskaja Pušča – the national biosphere reserve and UNESCO World Heritage sight, one of the largest remaining parts of the primeval forest in Europe.
Čarnaŭčycy – a village that preserves the Catholic church from late 16th century, one of the eldest monuments in Belarus.
Ružany – a settlement with the remains of the magnificent palace and churches from 16th – 17th centuries. The palace of Ružany is often called "Belarusian Versailles" and is one of the most impressive and visited monuments of architecture in Brest voblasc 
Zakazieĺ – a village near Drahičyn with the impressive neo-gothic burial chapel.