A year-round temperature in the low seventies Fahrenheit.
A significant North American expat community and tourist destination, which brings with it a wide range of amenities from which to choose, ranging from hostels to luxury, health spas, reliable infrastructure, with English very widely spoken.
Fresh mountain air.
A small town, with a small town atmosphere, surrounded by relatively untouched natural beauty.
The ability, if you choose to venture away from the town, to visit rural, traditional Panama.
An abundance of outdoor activities, including zip lining, bird watching, rafting (certain times of year), hiking, and limited golf.
World famous coffee plantations.
Lots of spas and other health-related facilities.
Up until the early 2000’s, Boquete was a sleepy, almost completely unknown and unremarkable agriculture-based mountain village with almost zero tourism and very few people living in the area whose families hadn’t been there for generations. That changed with a series of events starting with the creation of Valle Escondido, a large residential development aimed at expats. Right around the same time, several magazines devoted to people considering becoming expats began to flourish, with one of the most popular very regularly touting Boquete as “the land of eternal springtime”.
As a result of the publicity and the natural beauty and temperate climate of Boquete, it became, arguably, the best known North American expat destination in the world, as a large expat community developed. That community now dominates the town, which, depending on what you’re looking for, could be good or bad.
From David: there are several refurbished school buses leaving roughly every 45 minutes until 9:45 PM. Travel time is a little over 1 hour and cost is $1.75 which you pay when getting off. Look for the old USA school buses with the biggest line and a big "Boquete" sign painted across the top front.
From San Jose in Costa Rica: there is one morning bus leaving from the Tracopa terminal at 7:30AM ($21). It takes about 8 hours to get to David, including the Costa Rica-Panama border crossing, and arrives at the David Bus Terminal. Panama immigration officers can be strict, and tourists must often provide proof of onward ticket out of Panama, at least $500 cash or bank statements, and credit cards. From David see above.
From Panama City by airplane: AirPanama  has daily flights from the Albrook Domestic Airport in Panama City to the David Airport. The flight takes about 40-50 minutes, prices range from $100 (retired discount) to $150 each way.
From Panama City by bus: There are regular buses from the Albrook Bus Terminal, run by at least three companies (Panafrom, Padafront, and Terminales David); between them, there is a bus leaving about every hour. Daytime fares (as of February 2011) are $15.00; there are also nighttime express buses for $18.50. It is an air conditioned bus and gets very very cold. The bus makes one 30-minute meal and bathroom stop in Santiago, halfway in between Panama City and David. It takes roughly eight hours to get there, as there is construction on the Pan-American Highway between Santiago and David as they are widening it to 4 lanes. Construction can sometimes delay traffic.
From Bocas del Toro: There is a twice-daily, $30-35 private shuttle (including water taxi to Almirante) between Bocas del Toro and Boquete 4 hours, as well as several daily public buses between David and Bocas, which are cheaper but take quite a bit longer 5-6 hours. Call or e-mail tour operators in Boquete for details.
Boquete is a very cozy mountain village so you won't have problems exploring the city on foot. The central plaza, in the middle of town on Main Street, is where the David-Boquete bus drops off incoming visitors and locals. For the smell and feel of the area there are scooter rentals at $25.0US for 4 hours as your means of transportation. In the surroundings you can also use taxi (one dollar brings you quite far) or the local area vans/buses which leave from the La Bruna Super Market 200 meters up the main road from the bus stop. Each local van/bus has written on the front window the areas that they cover, which are normally large loops up in the mountains in areas of Bajo Mono, Alto Quiel, Arco Iris, or Volcancito. There are also many tour companies that offer guided trips through the mountains to see waterfalls, coffee plantations, the cloud forest, white water rafting, and the Volcan Baru National Park. But if you want to rent a car and explore the area around Boquete, a four wheel drive may be safer, because the mountain roads do get washed out. Also be aware that there are no safe shoulders and no place for pedestrians to walk but the highway, so take caution traveling at night.
For some information, there is the Official Authority of Tourism, Panama (ATP) located a few minutes drive up the road back towards David, next to the Kotowa Coffee Shop, not in downtown Boquete. They have a small museum including some old photos of Boquete, as well as a beautiful view of the valley of Boquete.
There are only a few Authority of Tourism Panama (ATP) licensed official tour operators in Boquete, and it is highly recommended to book with one of them as they are licensed, insured, properly trained, and government-certified, with the safest and most experienced guides. The companies that are ATP licensed include, but not limited to: Boquete Outdoor Adventures, Boquete Tree Trek, and Explora Ya.
Boquete is known as the "Valley of the Flowers". Nestled in the western highlands of Panama, near the border to Costa Rica. Boquete shares some of the same mountain ranges with Costa Rica, as well as, some of the incredible wildlife and rain forests. However, because it is not as well known, and a 'road less traveled', prices are lower, and it is not as commercial. You can hike for 1/2 a day, or all day, and still have a rare chance to see the Resplendent Quetzal, or a Howler Monkey in the wild.
The Boquete Valley is rich with agriculture as well; strawberries, oranges, and coffee come from this region. There are two fairs to celebrate its floral culture. The Festival of Flowers and Coffee is for 2 weeks between January 12th and the 22th (the dates change sometimes by a few days) and the Expos Orchid Fair in March.
Adventure travel, which includes whitewater rafting, zip lining, ATV and jeep tours, cloud forest trekking, horseback riding, rock climbing and deep water soloing, is a key reason that Boquete, a fairly small town, is growing in popularity for European, American, Latino, and Asian travelers.
Boquete is known as a prime coffee growing region, with many farms exporting high-end coffee to Europe and Asia. The famous 'geisha' coffee, that was sold at auction, for $130 a pound, can be found growing on the rich Volcanic slopes.
Volcan Baru, Panama's highest point, is literally the easiest place in the world to see both of the worlds great oceans, on a clear day. It's a tough climb that can be done by hiking or jeep tour.
Plaza Los Establos, located on main street just south of the Main Square, is a nice shopping area with lots of little stores to browse through. Boquete Outdoor Adventures, Kotowa Coffee Shop, Habla Ya Spanish School, and the Transport Company (to Bocas), as well as several small family shops with eclectic souvenirs and great deals are all located in the Plaza.
Because of its temperate climate, moderate prices and relaxed living, it has become a favorite with expats and retirees. It is difficult to come to Boquete for just a couple of days and see all that it has to offer, and like many, you may find yourself here for a longer term stay.
Whitewater River Rafting on the Chiriquí Viejo River--Whitewater rafting in Boquete is some of the best in the world, and certainly an experience not to be missed. The Chiriqui Viejo River offers a super fun day of continuous Class 3 Rapids on a jungle run with nice warm water. A few companies offer full day rafting excursions or (when the conditions are right) whitewater kayaking and inflatable kayaking for all levels on several rivers around Boquete. It's a full day trip leaving in the morning and returning in the afternoon, with lunch and drinks usually included at the river. Rafting ranges from $65-$90, kayak $65-$100. Boquete Outdoor Adventures and Boquete Mountain Safari offer rafting trips year-round.
Visit a Coffee Plantation-- 2 to 4 hours: Boquete is known for the excellent coffee-growing conditions that make for some of the best in the world. Even if you aren't an avid coffee fan, a coffee tour is a great way to understand the culture and recent history of Boquete. Cafe Ruiz or Kotowa for a larger and more industrial form of Coffee Tour. For a more intimate small-farm experience visit Finca Dos Jefes which also offers an in-depth roasting and tasting. Cost for most coffee tours around town is usually $30 pp.
Zip Line through the Canopy of the Cloud Forest -- Boquete Tree Trek offers a zip line experience in the cloud forest with 12 lines of over 5 kilometers in total. It is located on a coffee farm, with beautiful views of Boquete, as well as an adrenaline-rush like no other, soaring through the cloud forest. Office is located in the Kotowa Coffee Shop in Plaza Los Establos. Cost $65 pp.
Jeep tour to the top of Volcan Baru4x4 Boquete There are a number of companies in the Boquete area capable of providing jeep transport to the top of the local Volcano, including A1 Private Tours who provides an action-packed 4x4 driving tour to the top of the volcano for the sunrise, for $150 per adult, $75 per child. Levels of service vary from one to the next and so does their ideals about environmental impact. It is possible to book a jeep through tour operators in town.
Hiking to the Top of the Volcan Baru - Though there are other options, but ANAM (Panama's Environmental Protection Organization) has encouraged local tour guides to recommend the more environmentally friendly method of hiking to the top of Panama's highest point. Expert Guides can be found by stopping by the offices of many tour operators in town. The hike is around 4-7 hours, strenuous, up a steep dusty dirt road. Then 3-6 hours back down, which is challenging on the knees. The climb is very difficult because of the length and steepness of the trail. Take into consideration the dramatic change in climates as you summit and be prepared with warm clothes, food, and water. This is the only place in Panama that temperatures occasionally drop below freezing and sadly two people have died on the top due to hypothermia. A guide is not necessary for hikers in groups as it is difficult to get lost on the road to the top, however Panama has recently been enforcing guided-only hikes in National Parks for the safety and prevention of lost tourists.
Hike the Quetzal Trail; so named because it is one of the homes of the rare Resplendent Quetzal. You can hike from Boquete to Cerro Punta (4 hours one-way gradual elevation gain), or the reverse. Most hikers will hike from Boquete to the "Mirador Las Rocas" and then return to avoid the more than 3 hour return by bus from Cerro Punta back down through David, and then back to Boquete. It is about a 4-5 hour one way hike (8 hours out and back), so it can be completed in one day. An experienced hiking guide is highly recommended as the recently repaired trail is extremely hard to follow, and often forks off into the cloud forest. Especially if you hope for any chance of spotting a Quelzal Bird, a guide is almost necessary in helping to locate a nest.
Golf Take advantage of the year-round spring-like weather and golf at the two golf courses at any time of the day. Both Lucero Golf and Country Club and Quebrada Grande Golf Course are open to the public.
Hot Springs Caldera - Hot and Bubbly mineral water right next to the Caldera River! Take a dip in both hot and cold. Taxis currently charge $30 to $36 for the round-trip journey. There are also a few inconsistent buses between Boquete and Caldera - from the bus stop in Caldera it's about an hour walk to the hot springs. After the bridge over the river, the real hot springs are to the left. Tourists that book a tour with a tour operator in town are taken to the hot springs with some daily departures for fun evenings soaking in hot water and sharing stories over the sunset. The Hot Springs entrance is difficult to find to on your own and is on private property which has a $3 entrance fee. Going with a group is recommended.
Horseback Riding in The Mountains of Boquete -- Most horseback riding tours are located in Caldera, 20 minutes drive back down toward David from Boquete. It is best for beginners up to experienced riders, and offers a nice trail ride with beautiful views of Volcan Baru. This tour is normally $35, but can usually be combined with the Caldera Hot Springs for a $55 half-day activity.
Yellow Jeep Tours crossing river on the way to the Caldera Hot Springs
Boquete Rock Climbing, ☎ +50767647918. Expert rock climber Cesar takes prospective scalers to an unusual Basalt volcanic rock face just outside of town. There is one 5.6 path, several 5.9 paths, and even several harder routes. $45 for 3 hours, with harnesses and ropes provided. All you can climb, which makes for an excellent half-day activity for beginners to experienced climbers. For experienced climbers, deep water soloing is also offered in Caldera at the Cangilones water canyon, which can be booked with tour operators in town. edit
Boquete Mountain Safari Tours (The Famous 4 x 4 Yellow Jeeps), Main Street (Center of Town right next to Banco General), ☎ 507-720-1147, . Ride in the yellow open air jeeps; Cloud Forest Safari's; Horseback Riding; Hiking; Caldera Hot Springs; Coffee Tastings. Also, trips up the Volcan Baru; either hiking or 4x4 driving. Shuttle service to Bocas from Boquete, or Boquete to Bocas del Toro.edit
This is the bread basket of the country, so the food that is served in the restaurants is very fresh, and quite varied, reflecting its early European beginning and its gaining international popularity. 
Bistro Boquete, (On the main drag, several blocks up from the square on the left). This bar and restaurant which is run by Panamanians has an excellent chef and gives great value. The tortilla soup, watercress salad, and pesto salad are nice starters (each for around $4), and the salads can be turned into a meal by adding an accompaniment of trout for less than $3. The flavors here are interesting but not overpowering.US$8-$13 for a meal plus tip. edit
Fonda de la Merry, (Walk South from the town square one block--at the corner near bridge, where Duran Coffee is), ☎ 507-6519-3209. 7 am to 7 pm. For a real local experience, this bright green restaurant is the place. Don't be put off by the spartan atmosphere. The warmth of the owner/server Maria, and the quick serving of excellent local food capture one's focus. The hojaldres, deep-fried pancakes, are a nice accompaniment to the vegetarian scrambled eggs, and the papaya, pineapple, and banana fruit salad is enough for two people. As a bonus, Maria speaks Spanish slowly and clearly, and cheerfully helps those who are learning.US$3 for breakfast, US$4-$5 for lunch. edit
El Casona Mexicana, (Walk South from the town square for about 8 minutes.). Very good Mexican food and large portion sizes. Various Mexican folk tunes play in the background. Good value. US$5 - 8 main. edit
The Rock, Ave. 11 de Abril Palo Alto, ☎ 507-720-2516, . 12:00 md - 9:30 pm. Because of the climate and dedication of its producers, Boquete offers an incredible collection of fresh food products. With the use of these top quality products and contemporary technical knowledge, the Rock is a higher-priced restaurant with exquisite food including pastas and a very rich suckling pork dish. Stimulating your senses every day is fundamental to provide an incomparable experience at THE ROCK. International food.from $9.00. edit
Morton's Bakehouse, Plaza San Francisco, Alto Boquete, ☎ 730-8499, . M-F 9to5, Sat 9to3, closed Sun.. Best bagels, Reubens, artisan breads - Rye, sour dough, multigrain, baguettes, cheesecake, rugelach. Artisan bread clases offered. Call for details. Original fine art, jewelry, baby knits in the gallery. Look for the blue door! Trip advisor recommended.75 cents - $6. edit
Big Daddy's Grill (freshest fish tacos in boquete), Main Street (1 minute walk down from Main Plaza), . 12:00-9:00 pm Tues-Sun.. Home of Boquete's original grilled fish taco, Big Daddy's prides itself on serving only the freshest fish which was swimming yesterday, as well as a killer margarita, delicious buffalo wings, and organic salads. Good service. One of the favorite restaurants with both locals and tourists in Boquete. $7.95. edit
Restaurante Mango at Isla Verde, Calle 2da Suroeste (Avenida C Oeste) (The mango colored building at the turn to Valle Esconidio), ☎ 507-720-1539, . 11am - 8pm. Chef Craig Miller (formerly of Rancho de Caldera) and his wife Maureen bring a fresh perspective to Panamanian cuisine by integrating Craig's background of ethnic flavors and the abundance provided by Panama's tropical environment. Fresh fish from two oceans, a year-round growing season and a burgeoning food culture all allow for Chef Craig to focus on distinctive plates that are unique to Boquete and Panama.$6-$18. edit
Zanzibar. This chilled bar offers live music at weekends. Located on Main Street, up the road near the Art Cafe and La Posada Restaurant.edit
*Boquete Jazz&Blues Festival, Boquete/Chiriqui, ☎ +507-6519-7876, . The open-air annual Boquete Jazz&Blues Festival takes place in March every year. It features world-class Blues as well as Latin Jazz at the open-amphitheater in Valle Escondido. Admission passes range from $15/day to $25 for a festival pass.editedit
Mango at Isla Verde, Calle 2da Suroeste (Avenida C Oeste) (The mango colored building at the turn to Valle Escondido), ☎ 507-720-1539, . 8am. Chef Craig Miller (formerly of Rancho de Caldera) and his wife Maureen bring a fresh perspective to Panamanian cuisine by integrating Craig's background of ethnic flavors and the abundance provided by Panama's tropical environment. Fresh fish from two oceans, a year-round growing season and a burgeoning food culture all allow for Chef Craig to focus on distinctive plates that are unique to Boquete and Panama.$6-$18. edit
Mango at Isla Verde, Calle 2da Suroeste (Avenida C Oeste) (The mango colored building at the turn to Valle Escondido), ☎ 507-739-5027, . 8am-9pm. Serving wine and local microbrew.$6-418. edit
Mike's Global Grill (Local, Sustainable, and Affordable), Main Street (Walk 8 minutes down from the Plaza, across from Sugar and Spice), ☎ +507 730-9360, . Chef Michael is dedicated to international cuisine using local ingredients. Mikes' offers a dive bar atmosphere with world class prepared casual cuisine. The decor is low key and a bit rustic—this a place for a great meal, which doubles as a hang-out & a sports bar with a large TVs, couches, WIFI, and weekend evenings may have live music. Try the hamburgers, the Chicken Pad Thai and the Falafel. edit
There are several inexpensive hostels around and within a few blocks the central park.
Casa Romero (Traditional Home), Ubicada sobre la Calle Principal de Boquete a 1.8 kms de la Iglesia Catolica del Pueblo, justo antes del Puente sobre el Rio Caldera, y a la derecha de la señalizacion hacia Alto Lino y Los Naranjos. (Located on Boquete Main Road, at 1.8 kms from Boquete Catholic Church, just before the bridge over Caldera River heading toward Alto Lino, and to the right of Alto Lino and Los Naranjos road signs.), ☎ +507 6679-4404, . checkin: 02:00pm; checkout: 11:00am. [Casa Romero http://www.BoqueteCR.com] An exclusive traditional Boquete house overseen Caldera River and Volcan Baru. Special for big families or group of friends. It has 3 Bedrooms, each with its private bathroom. It can accommodate up to 12 persons. Reservations are required, it does not take walk-inRooms with private bathrooms starting $125.00. edit
Hostal Palacio, right opposite the bus station and the central park. It is a bit noisy since it's right on the street, and it's important to mind your belongings. Be aware about the owners and the hostel as many tourists have had some troubles. 20 US for dorm. Across from the main plaza, but there are many much better places to stay.
Hostal Nomba (Adventure Backpackers), Los Naranjos (5 minute drive up from the bus stop), ☎ +507 720-2864, 6497-5672 (email@example.com), . checkin: 13:00; checkout: 11:00. Hostal NombaCheap, friendly micro-hostel just up the road from the center of town. Run by an extremely welcoming young couple. BBQ, fun and peaceful environment, and comfy hammocks in the common area. They also rent a full range of outdoor equipment for local expeditions, and organize a wide range of adventure tours in the region. WiFi, free basic breakfast of fresh bread and coffee. Adjacent is the office of Mirador AdventuresDorm rooms starting $11, privates starting $35. edit
Rancho de Caldera Eco-Resort Boquete Panama, Caldera (25 minutes from downtown Boquete, 40 minutes from David), ☎ Toll free from Canada and USA: (877) 810-0898 or (216) 220-0192, . checkin: 2:00; checkout: 11:00. Rancho de Caldera (http://www.ranchodecaldera.com) is a serene and gorgeous eco-resort (completely off the grid, on renewable energy year round) nestled in the mountains of Chiriqui; accommodations include large, spacious rooms, each with a glasswall overlooking the mountains to the east, A/C, iPod docking station, TV, mini-refrigerator and free Internet. Activities include horseback riding, hiking and swimming in a beautiful infinity-edge pool. Hot springs nearby. Rancho de Caldera, a leader in innovative, clean energy hospitality, has been recognized by Green Globe International, Rain Forest Alliance and Sustainable Travel International. CLOSED AND FOR SALEedit
Boquete Mountain Casitas, Boquete, Chiriqui (Boquete is a 30 minute drive from David), ☎ 507-6613-1472, . checkin: 2:00; checkout: 11:00. Some of the casitas are located within walking distance to the village while others are on private estates in the mountains. Has one 2 bedroom, 2 bath in the middle of an Organic Coffee Farm.edit
Hostal Gaia, Boquete (On downtown Boquete, Avenida B Oeste and Calle Landero Acosta.), ☎ 7201952, . checkin: 12:00; checkout: 12:00. Here at our hostel you will find a pleasant atmosphere, a fully equipped kitchen and a dining room, WiFi, camping area, and laundry facilities. CLOSED AND CHANGING LOCATIONS from $13. edit
Boquete Paradise, ☎ +507-720-2278. Next to a roaring mountain stream and walking out with a view of the 11,500 ft. Volcan Baru right out of your front door. Each unit has a two bedrooms suite with full kitchen, that sleeps eight people. Breakfast is served in the morning$60 - $189. edit
Hostel Mamallena, Parque Central (Right on the Central Park, 30 metres from the bus stop), ☎ 720 1260, . This hostel is popular with backpackers. Free pancake breakfast, WiFi internet, lounge, patio. Also has private rooms with private bathrooms. Information and tours are available.edit
Panamonte Inn & Spa, Ave 11 de Abril, Boquete, ☎ +507-720-1327, . Famous for its gracious hospitality, charm and exquisite cuisine, The Panamonte is the true definition of a country inn: a warm and friendly place for travelers seeking a pleasurable ambiance and personalized attention, a home away from home. Located at the foot of Barú Volcano, the Panamonte is the perfect base for exploring the Chiriquí Highlands, and it is the only full-service lodging option in Boquete, offering a deluxe spa, fireside lounge, excursion planning, and a regionally renowned gourmet restaurant.edit
Valle Primavera, (8 minutes, walking, heading South from the central square), ☎ +507 6674-5761, . checkout: 11:00. Offers bed-and-breakfast style accommodations in a tranquil atmosphere. Rooms are comfortable and include private entrance, private bathrooms with hot water, cable television and WiFi. Breakfast included. Ideal for families, though it becomes noisy around 8am every morning, so do not expect to lie-in.US$38 (inc taxes) for 1 - 3 person room. edit
Hotel Isla Verde, Calle 5a Sure (Behind the School Josefa Vasquez), ☎ +507 720-2533, . checkin: 1pm; checkout: 11am. Isla Verde offers six roundhouse cabins, six suites and a little casita, all fully equipped, next to the river in a tropical garden with mountain views. Walking distance to town but peaceful. On-Site massage available.$ 90 - $ 150. edit
Momentum Panama (momentum panama), Alto Boquete (Left side of road going towards Boquete in alto b oquete), ☎ 7204385, . checkin: 10; checkout: 2. Momentum's fully-equipped cabins and B&B are set on a green plateau, perched on the edge of a valley alongside the rambling Rio Cochea. There’s plenty of room to wander for you and your family. Small groups welcome. (Maximum capacity 26). At 800 mt. (2,625 ft.), the temperature and distinct lack of humidity is always refreshing. Enjoy the peace, privacy and serenity of the unique location. Better yet, it all comes with spectacular ‘straight-on’ views of Volcan Baru, at 3,475 mt. (10,750 ft.), Panama’s highest peak. Located about a 15-minute drive outside of Boquete, back towards David.49. edit
The Riverside Inn, Ave. 11 de Abril, Palo Alto, ☎ 507-720-1076, . checkin: 3:00 pm; checkout: 12:00 md. For travelers looking for comfort and some of the best service and amenities in town, the Riverside Inn in Boquete offers that something special that only a personal attention to detail provides. Delight in the sounds of nature on the banks of the Palo Alto River, just minutes from the town of Boquete, Panama.edit
Hostal Refugio del Rio, Av B Oeste (two blocks north of Av Central near Plaza), ☎ 720-2088 or6676-5786, . checkin: 1 pm; checkout: 11 am. Clean, comfortable facility situated on the rambling river. Nice grounds including a hot tub/Jacuzzi. Kitchen privileges. Favored by many German and Swiss tourists.dorm 13; semi private 31; private 36; cabina 38. edit
Hotel Refugio de Montana, Volcancito Road, Boquete 507, Panama, ☎ 730-8355, . checkin: 1 pm; checkout: 11 am. A quite hotel in the mountains for those looking for a budget hotel style accommodations.double 55; additional person 10. edit
Boquete Green (at 3 minutes from the bus stop), Avenida A Oeste (Arriba de la Escuela Josefa Montero de Vasquez), ☎ 507-730-9509, . checkin: 3:00p.m.; checkout: 12:00pm. Free Wifi internet, Also we have other private rooms with private bathrooms, Information and ask for your favorite activities and tours, you can find several tipical restaurant at 5 minutes. book at firstname.lastname@example.org. edit
David - Take one of the frequent buses to David (Panama). The old school buses depart hourly from the Boquete Main Plaza, near the old train car and next to Baru Restaurant. Just look for the old school bus that is parked there, and if there isn't one, you won't have to wait long for the next one to pull up. $1.75 to get down to the David main bus station.
Boca Chica - Swim, sport fish, sea kayak, and snorkel in the cool, aqua-marine clear waters of the Gulf of Chiriqui, a National Marine Park just an hour and a half drive away from Boquete. This small town hasn't been spoiled with massive tourism yet, so if you want to see a real side of Panama, go for a day trip or stay overnight in the charming fishing village of Boca Chica, or on one of the island resorts on Boca Brava or Isla Palenque.
Bocas del Toro - Take a private shuttle for the 4 hour journey to Almirante, and then the water taxi, which is included in the ticket price, to Bocas del Toro. Two companies in town offer the daily shuttle: 8:00 am departure ($30) from Hola Panama in the Mamallena Hostel. 9:00 am departure (with hotel pickup) ($35) from the Transport Company in Plaza Los Establos on Main Street. Advanced reservations are highly recommended as the shuttles fill up quickly.
Panama City - From the David bus station (see how to get to David above), there are buses hourly providing the 8 hour transport to Panama City for $15-20, with a 30-minute meal and bathroom break in Santiago. The David Airport offers 40-minute flights with Air Panama to Panama City for around $150+ one-way.
San Jose, Costa Rica - There are a few buses a day that leave from David (see how to get to David above) to San Jose. The bus is about $20 and takes around 8 hours, which includes the border crossing at Paso Canoas. At the border, you will get off the bus, have your luggage inspected, get your Panama exit stamp, walk across the border to the Costa Rica immigration, and get your entrance stamp, luggage inspected again, and wait for the bus to get back on. Costa Rica immigration can be strict, and tourists will usually need to provide some sort of confirmation of an onward ticket out of Costa Rica within 90 days of entering. Onward tickets can include a flight out of San Jose, or a bus ticket coming back to Panama.