This city in the very south of Turkey was an important centre of early Christianity, with some of the first non-hidden churches. Today it’s a truly multicultural place, where you can hear prayers in many different tongues. Many denominations of Christianity (Greek Orthodoxy, Syriac Christianity, Roman Catholicism, Protestantism to name a few) and Islam (Sunni and Alawi), as well as Judaism, are all represented with their dedicated temples in Antakya.
Ethnically, Arabs constitute almost half of the population whereas the other half is constituted by Turks. Arabs in the city speak Levantine (Shami) dialect of Arabic, which is also prevalent in Syria, Lebanon, and Jordan.
The city is not located on the sea-shore, but the Asi River (formerly known as the Orontes River) flows through the city center.
Domestic flights are available to Hatay Airport, 25 km from the city center. However, the nearest international airport is located in Adana, a couple of hundred kilometres to the north. The 'Havas' bus runs from the airport hourly to the city centre for 9 lira, and takes around 20-30 minutes. If you need to get back to the airport, the Havas leaves from the front of the 'Buyuk Antakya Hotel' (on the river, close to the Mosaic Museum; it' a huge resort style hotel, you can't miss it) every half hour most days, but check the Havas website for specific departure times. This is a lot cheaper than a taxi! Please note that you will have to flag the Havas bus down from the front of the hotel, as not many people utilise this service, so make your presence known as it drives past.
You can also use Dolmuş Taxis in order to get to the city center. Many dolmuş taxis wait just in front of the airport and as soon as any four customers are gathered, the taxi heads towards the city. The taxis charge approximately 10 lira per person. All in all, if you accept to share the taxi with other passengers, taking a cab is preferable to Havaş as the taxi drops you off in whichever part of the city you want to get out while Havaş only stops at specific points.
Has Turizm  operates comfortable buses from all major cities in Turkey. There are also bus connections with Aleppo, Syria.
The otogar is located about 7 kilometers from the city center. Once you arrive look for minibuses to take you within walking distance of the center. Many of the hotels are located on Istiklal street.
To get from Antakya to Aleppo in Syria, the best option is to catch a bus from the central bus station (otogar) outside of town. It's too far to walk there, but there are bus connections from the town centre. The journey to Aleppo should cost you 10 Turkish Lira (2009). Keep in mind that the last bus (during Ramadan) leaves at 11AM! This might be different outside of Ramadan, though. You can also try to catch a taxi from the town centre, which can be fairly difficult, as you normally have to wait until there are enough people sharing the taxi. The journey should cost you around 25 Turkish Lira each if the taxi gets full. If you don't want to wait, you can pay for the whole taxi and depart immediately, which is going to be about 100-120 Turkish Lira.
Don't try to cross the border step by step! The Lonely Planet mentions this option, which means you catch a bus to the Turkish border control, hitchhike to the Syrian border (which is about 5 km away, and you are not allowed to walk) and then take a taxi from there to Aleppo. You should be prepared for an extremely time-consuming trip. There's no other possibility to get from the Turkish border control to the Syrian one than waiting for a car to hitchhike. This can take some hours. At the Syrian border neither buses nor taxis are to be found, so you will have to hitchhike again. Most people will charge you for hitchhiking, and normally they will try to rip you off. Speaking Turkish and/or Arabic will certainly help, but if you don't, this trip is going to be really difficult. Apart from that it's more expensive than the direct bus.
Mosaic Museum (Mozaik Müzesi) or the Antakya Archeological Museum in the city has the second largest collection of classical/Roman mosaics in the world. The museum also features a good coin collection, artifacts from the Iron and Bronze ages found in sites nearby and a very impressive sarcophagus with great reliefs. You can check many items from the collection through the official website of the museum: 
One of the oldest churches of Christianity, Church of St. Peter, is a must see in Antakya. Entrance to the church is 8 lira (as of Nov 2010). The church is about a 30 minute walk from the museum. To reach the church you need to go across from the museum, through the bazaar and at the end (when you exit the bazaar) make a left and go on for about over a kilometer - the church will be visible up on the hillside.
Büyük Antakya Parkı is the park that is located just in the midst of the city, by the River Asi and behind the famous mosaic museum of the city. Many locals visit the park during the day, and especially early in the morning to do sports. Note that there are many open air tea houses within the park, hence it's the address to go for a tea or coffee or hookah when the weather is nice.
Titus Tunnel, Cevlik, Samandağı, Antakya. The Titus Tunnel (Titüs Tüneli) is a Roman engineering marvel. During the reign of Emperor Vespasian (69-79 AD), the Roman governors of Seleucia Pieria (Samandag), the port city for Antioch ad Orontes (Antakya), decided to divert a river. They put Roman legionnaires, sailors and prisoners to work cutting a channel along and through the rock for about 1.4 km (nearly a mile). Continued under Emperor Titus (79-81), inscriptions tell us it was completed during the reigns of the Antonine emperors decades later. Today the channel is dry, but still worth a visit. A small parking area and entrance is just inland from the beach at Samandag. A path ascends along the channel, open to the sky, up and down steps and rocks, to where an arched limestone footbridge crosses. Above the footbridge, the channel continues into the solid rock. You'll need a powerful flashlight/torch to continue.edit
Thanks to the large laurel (Laurus nobilis) groves on the mountains surrounding the city, laurel soaps (defne sabunu, also known as garlı sabun locally), which are said to have some benefits on the skin and hair, are unique to this city and are made of local olive oil with some laurel extract stirred in.
City is also famous for silk production which is woven in the traditional way.
In the ancient bazaar area you can find the regional spices, leather shoes and hand-made wooden objects.
The city is known for its tasty cuisine (one of the most delicious in Turkey), which has many Middle Eastern influences. One of the must eats in Antakya is a dessert called Künefe, which is a shredded pastry with cheese. There are many Künefe houses scattered in the city, but they are especially concentrated in the main square of the city, Köprübaşı. Hatay Künefe and Kral Künefe, both located in Köprübaşı, are among the most famous Künefe houses in the city.
There are many restaurants in the city center, but most of them serve döner and other fast food. In order to try local cuisine, try Anadolu Restaurant (in Saray Caddesi), Sultan Sofrası Restaurant (in Köprübaşı) or Sveyka Restaurant (in Kurtuluş Caddesi). As for döner restaurants, Restaurant Nuri and Restaurant Abdo (both in Saray Caddesi) are the most famous ones for Et Döner (beef döner) whereas Kebo, a tiny place located in Atatürk Caddesi, is the most famous place for Tavuk Döner (chicken döner).
Note that Harbiye, a touristic municipality which is 10 km away from Antakya, has many restaurants as well and people frequently go from Antakya to Harbiye for long dinners.
Ornikos, Pisirim Merkezi, Fish Market Area. To eat like the locals, go to the Fish Market and buy a couple of fresh ones from the iced bins, then take them to the nearby cafe Ornikos where for a small fee you can have your fish cooked and served up with house salad and a beer.edit
Cabaret Bar, Central Antakya, . An upstairs bar which opens out on the first floor of the building, with a balcony, and front windows overlooking the pedestrianised street below. As of June 2011, there was a live band playing Turkish covers, and it looks like live music is a regular feature. Beers are inexpensive and the waitress service good. Located in Saray Caddesi.edit
Saklı Ev Cafe, Central Antakya, . An old Antakya-style house, restored and transformed into a cosy café. It's not mostly famous for its food, but rather for its ambiance. Serves a variety of food and drinks, including beer. It's one of the places where you can try one of the local desserts, "haytalı". The name of the café means "the Hidden House". It's located near the end of Saray Caddesi where it meets with Kurtuluş Caddesi.edit
Hotel Mozaik, İstiklal Caddesi 18 (Sultan Sofrası Üstü), ☎ +90 326 215-50-20/21/22/23. Located in the city center, the hotel rooms are very clean. Quoted 75 lira with breakfast for a single room, 100TL for a double (Nov 2010 prices)edit
Onur hotel, Istiklal cadessi. A 3 star hotel, clean rooms and bathroom, Quoted 60TL for a single (Nov 2010 prices), staff speaks Englishedit
The Liwan Hotel, Silahli Kuvvetler Cad. No 5, ☎ +90 326 215 7777, . First and only boutique hotel in Antakya. The building was used as presidential residence of the former Syrian president. Central location with walking distance to historical places. edit
Savon Hotel, Kurtuluş Cad. No:192, ☎ +90.326 214 63 55, . Former soap factory converted to a hotel in 2001, located in the old city area of Antakya, between the Mosaic Museum and the Church of St. Peter.edit
Hotel Saray, Hürriyet Cad. No. 3 (A multi-story building in the pedestrianized street.), ☎ +903262149001. Cheap and cheerful, popular with down-on-their-luck freelance journalists. Hot water, wi-fi, simple breakfast served from 7-10 a.m. Rooms are clean and relatively quietSingles start at 50TL. Doubles for 80. edit
Antik Grand Hotel, Hürriyet Caddesi, No:10 Antakya - Hatay (email@example.com), ☎ 0326 215 75 75, . Antik Grand Hotel is situated in the city centre of Antakya, offering peace with its comfortable accommodation and riverside location. Elegantly decorated, the luxurious rooms of the hotel feature air conditioning, cable TV and free Wi-Fi. All rooms of Antik Grand have floor-to-ceiling windows and classical curtains. Telephone, minibar and a private bathroom are also included. Some rooms offer a seating area and a hot tub. Archeologie Museum is just a 5-minute walk from Antik Grand. Many historical buildings and mosques are in walking distance. Saint Pierre Church is 2.5 km and Antakya Castle is 3 km away.edit